Treatment of GME
Immune-suppression with corticosteroids (such as prednisolone) remains the corner stone of treatment for GME. Once the disease is controlled, you can begin to gradually drop the steroid dose until you reach the minimum dose required to control the disease. This process can take several months and relapses are common. Response to prednisolone is variable and results are much better if additional medications are added.
Cytosine arabinoside, a chemotherapy agent, can be added to prednisolone for a much better response. Monitoring is required with a medication this it can cause bone marrow suppression.
Cyclosporine is an immunomodulator somewhat different from the chemotherapy agents described above. It can be combined with prednisolone to treat GME without the bone marrow suppression side effects.
A new drug called leflunomide has been released to treat immune-mediated diseases of a type that includes GME. This is a relatively expensive treatment, which has limited use but it remains as a possible alternative to corticosteroid use for dogs that do not tolerate corticosteroid side effects.
If seizures have been a manifestation of GME, either disseminated or focal, medication will be used to control the seizures.
Ophthalmic GME also uses oral corticosteroids for therapy but may also employ topical ones. If glaucoma results from GME, then therapy for it is necessary. Again, therapy for this result of GME is addressed in a standard way; no specific GME glaucoma therapy is needed.